Diflucan 150mg 1'sDIFLUCAN ONE contains its active ingredient fluconazole 150 mg as capsule given orally, it is indicated for vaginal candidiasis and is administered orally. Use in Adults For vaginal candidiasis, fluconazole 150 mg (DIFLUCAN ONE) should be administered as a single oral dose. The median time to onset of symptom relief following a 150 mg single oral dose for the treatment of vaginal candidiasis is one day. The range of time to onset of symptom relief is